Congenital Disorders Affecting Multiple Body Systems

Conditions covered

The section includes a specific adult listing for non-mosaic Down syndrome. Other congenital disorders may be evaluated under the body-system listings that match their documented effects, such as neurological, cardiovascular, or musculoskeletal impairments.

Key listings in Section 10.00

• 10.06 — Non-mosaic Down syndrome

  Provides criteria for non-mosaic Down syndrome, including specified laboratory or medical documentation paths.

• Other applicable body-system listings — Impairments caused by a congenital condition

  SSA evaluates specific functional effects under the relevant body-system criteria when no Section 10.00 listing applies.

These are plain-language summaries, not the full regulatory criteria. Review the official Blue Book for the complete requirements and definitions.

Evidence SSA may consider

• For Listing 10.06, the Blue Book describes the types of laboratory, physician, and other documentation SSA considers. The exact evidence needed depends on the path being evaluated.
• For other congenital disorders, collect records that document the diagnosis, affected systems, treatment, examinations, testing, and functional effects over time.
• When several systems are affected, organize the record so each condition and its combined effects are clear to SSA.

If the listing is not met

If the criteria in Section 10.00 are not met or medically equaled, that does not end the evaluation. SSA may consider each resulting impairment under its own listing and evaluate the combined effects.

If no listing is met, SSA assesses RFC and proceeds to Steps 4 and 5. The RFC should reflect supported physical, mental, sensory, and attendance-related limits caused by all impairments together.

Related resources

• See the five-step disability process
• Read about residual functional capacity (RFC)
• Explore the Medical-Vocational Grid Rules
• Browse common condition guides
• Find SSA hearing offices